PERIPHERAL IMMUNITY IN AGING AND PARKINSON’S DISEASE
OPEN CALL for 1 Research Fellow position (12 months)
OPEN CALL for 1 Research Fellow position (12 months)
The Center for Research in Medical Pharmacology, University of Insubria (Varese, Italy), and the Movement Disorders Centre, Neurology Unit, Department of Translational Medicine, University of Piemonte Orientale (Novara, Italy), have an open Research Fellow position to work on the role of peripheral immunity in aging and Parkinson's disease, with particular regard to T cells as biomarkers of immunoaging and their relationship with frailty and PD progression.
The ideal candidate for this Research Fellow position is expected to hold an MD or BSc degree or similar, and to have adequate experience in biomedical research. In particular, s/he is expected to learn and apply:
- flow cytometry techniques for the characterization of main innate and adaptive immune cell subsets in whole blood;
- cell separation and culture protocols, with particular regard to human T lymphocyte purification and culture from buffy coats and whole blood;
- ex vivo/in vitro functional models of immune response.
Knowledge of scientific english and documented ability to write scientific reports and manuscripts will be a preferential requirement.
The position will be last for 12 months. Salary will be 1.200,00 €/month (net amount). The position might be extended for additional 12 months upon positive assessment of results and availability of funds.
For detailed information about rules that will apply to the position please see here.
An official call detailing deadlines and procedures will be soon available. Potential applicants are meanwhile invited to submit a preapplication/motivation letter, together with a curriculum vitae including a full list of publications and eventual names for references, at their earliest convenience, to farmacologia.medica@uninsubria.it. E-mail submissions must include the subject “Research Fellow position”.
References
Storelli E, Cassina N, Rasini E, Marino F, Cosentino M. Do Th17 Lymphocytes and IL-17 Contribute to Parkinson's Disease? A Systematic Review of Available Evidence. Front. Neurol., 24 January 2019 | https://doi.org/10.3389/fneur.2019.00013
Kustrimovic N, Comi C, Magistrelli L, Rasini E, Legnaro M, Bombelli R, Aleksic I, Blandini F, Minafra B, Riboldazzi G, Sturchio A, Mauri M, Bono G, Marino F, Cosentino M. Parkinson's disease patients have a complex phenotypic and functional Th1 bias: cross-sectional studies of CD4+ Th1/Th2/T17 and Treg in drug-naïve and drug-treated patients. J Neuroinflammation. 2018 Jul 12;15(1):205. doi: 10.1186/s12974-018-1248-8.
Cosentino M, Kustrimovic N, Marino F. β2-Adrenergic Agonists for Parkinson’s Disease: Repurposing Drugs at the Crossroad of the Brain and the Immune System. BrainImmune - Trends in Neuroendocrine Immunology (online), 2 december 2017.
Kustrimovic N, Rasini E, Legnaro M, Bombelli R, Aleksic I, Blandini F, Comi C, Mauri M, Minafra B, Riboldazzi G, Sanchez-Guajardo V, Marino F, Cosentino M. Dopaminergic Receptors on CD4+ T Naive andMemory Lymphocytes Correlate with Motor Impairment in Patients with Parkinson'sDisease. Sci Rep. 2016 Sep 22;6:33738.
Marino F, Cosentino M. Multiple sclerosis:Repurposing dopaminergic drugs for MS--the evidence mounts. Nat Rev Neurol. 2016 Apr;12(4):191-2.
